In Thailand during the pandemic of Covid-19, it was firmly believed that a traditional herb could cure the symptoms and reduce the incubation time of the SARS-COV virus. Despite all that, there are also many other diseases and symptoms that were believed to be cured better by herbal antibiotics. This research aims to investigate the performance of herbal antibiotics, in comparison to the modern antibiotics which are internationally recognized. The research has been done by gathering 6 samples of antibiotics with 3 of modern antibiotics, Amoxicillin, Roxithromycin and Norfloxacin, and 3 of herbal antibiotics, Turmeric, Garlic, Green Chiretta (“Fah Talai Jone” in Thai language.) The medicines are added with recommended dosage per day of each, into serial diluted E. Coli cultures by using the plate pour method. All the samples were incubated for 72 hours and were taken out to collectively count the colonies. The alternative hypothesis of the research was that the modern antibiotics will perform better than the herbal antibiotics. As a result, the alternative hypothesis was proven true. Garlic and Roxithromycin work the best with 100% and the others relatively lesser. Green Chiretta on the other hand, had 32.38% efficiency which was the least.