In the ever-evolving landscape of the 2019 Coronavirus Disease (COVID-19) pandemic, the Centres for Disease Control and Prevention (CDC) diligently monitor the frequent emergence of new variants of the virus. This review delves into the intricate structural configuration of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2), its mechanisms of infection, and certain treatment options. Amid the various strategies for preventing and treating COVID-19, the significance of nutrition remains somewhat underestimated. Foods contain a vast array of substances, with specific compounds exhibiting antiviral properties and contributing to immune regulation and cellular defence against oxidative stress. In this overview, we focus on a specific compound - hesperidin, found in citrus fruits, renowned for their vitamin and flavonoid content. Hesperidin exhibits promising results in combating SARS-CoV-2, highlighting the potential of phytochemical interventions, including nutrition, alongside conventional therapies.