Genomic medicine implementation in healthcare systems can bring us one step closer to making personalised medicine a reality with major socioeconomic benefits Citizens and patients can nowadays widely benefit from genomic data analysis for accurate and timely diagnosis, effective treatments with less adverse events, and accurate profiling for disease prevention Implementation of genomics in healthcare is complex, and requires adjustments in the governance, structure and organization of health services, as well as dedicated investments Implementation is also dependent on the country context In the context of the 1 +Million Genomes 1 + initiative, we developed a Maturity Level Model ( for health systems to self evaluate the maturity of their genomic medicine practices, and define a path to optimization a MLM is tool for healthcare systems to self evaluate the level of maturity of their genomic medicine practices according to a common matrix,and to define a path to optimization A MLM pilot in eight European countries provided important information regarding common strengths, weaknesses and asymmetries across Europe