Abstract: Cyclosporine A is an immunosuppressant used in the prevention of immune denunciation of organ transplantation and it has been reported to induce cardiotoxicity and hematological alterations. Herbal remedy has been reported to possess a potential therapeutics efficacy due to their rich antioxidant properties and Gingko Biloba supplement has been reported for its antioxidant potentials. Hence, the present study was carried out to evaluate the effect of Gingko Biloba Supplements on cardioprotective and haematological parameters of cyclosporine-induced Wistar rats. The male Wistar rats were randomly allotted to four treatment groups (n=5), the group I-II was treated with normal saline and Gingko Biloba supplement respectively, and group III-IV was administered cyclosporine alone and Gingko Biloba supplement + cyclosporine respectively for fifteen days. The Wistar rats were euthanized after treatment and the blood sample was collected for hematological and biochemical analysis. The levels of cardiac biomarkers and antioxidant enzymes such as malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) were evaluated along with gross histopathological examination of the heart and pancreas. The P< 0.05 was considered to be statistically significant. The result obtained from these present shows that GBS significantly improved haematological parameters. GBS showed a protective impact in terms of improved heart and pancreas histology, as well as the antioxidant enzyme activity (CAT, SOD, GSH, and MDA). In conclusion, the Ginkgo biloba supplementation attenuated cyclosporine toxicity by stabilizing haematological alterations and cardiac dysfunction. Keywords: Oxidative Stress, Gingko Biloba Supplement, Cardiotoxicity and Cyclosporine. Title: EFFECT OF GINGKO BILOBA SUPPLEMENTS ON CARDIOPROTECTIVE AND HAEMATOLOGICAL PARAMETERS OF CYCLOSPORINE-INDUCED WISTAR RATS Author: William, Boulobellemowei Debekeme, Henrrietta Ogadimma Asuzu-Samuel International Journal of Recent Research in Life Sciences (IJRRLS) ISSN 2349-7823 Vol. 11, Issue 1, January 2024 - March 2024 Page No: 40-51 Paper Publications Website: www.paperpublications.org Published Date: 18-February-2024 DOI: https://doi.org/10.5281/zenodo.10675490 Paper Download Link (Source) https://www.paperpublications.org/upload/book/EFFECT%20OF%20GINGKO%20BILOBA%20SUPPLEMENTS-18022024-3.pdf