References: 1. "Oncolytic Viruses: Methods and Protocols" edited by Chunlai Zuo and Wei Cao 2. "Oncolytic Viruses" by Darren Shafren 2017, Molecular Therapy - Oncolytics 3. Ex Vivo Virotherapy with Myxoma Virus to Treat Cancer Nancy Y. Villa, Lina S. Franco, Grant McFadden (səh. 95-110) - 2020 4. Methods for Modification of Therapeutic Viruses Claudia A. P. Hill, Luca Bau, Robert Carlisle ( səh.7-290)-2019 5. Immunohistochemistry for Tumor-Infiltrating Immune Cells After Oncolytic Virotherapy Dipongkor Saha, Samuel D. Rabkin (səh.179-190) - September 2019 6. Generating Primary Models of Human Cancer to Aid in the Development of Clinically Relevant Oncolytic Viruses Brian A. Keller, Marie-Ève Wedge, Abera Surendran, Carolina S. Ilkow (Səh.271-284)- January 2020

Abstract The battle against cancer continues to evolve, with oncolytic viruses emerging as a groundbreaking and promising avenue for innovative treatment. This paper provides a comprehensive overview of oncolytic viruses, a unique class engineered to selectively infect and destroy cancer cells, eliciting an immune response against tumors. Beginning with a historical perspective, the narrative explores the mechanisms of action, types of oncolytic viruses, and notable clinical successes, including the FDA approval of a melanoma therapy.