Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles
Copyright policy )Calorie restriction and rapamycin distinctly mitigate aging-associated protein phosphorylation changes in mouse muscles
Calorie restriction (CR) and the treatment with rapamycin (RM), an inhibitor of the mTORC1 growth-promoting signaling pathway, are two interventions that slow down aging and promote the healthspan of animals, from worms to humans. Here we measured the phosphoproteomes of four muscles, soleus, tibialis anterior, triceps brachii and gastrocnemius, from adult (10 months), and geriatric (30 months) mice, the latter either untreated or, from 15 months of age, treated with RM or CR.
- University Hospital of Basel Switzerland
- SIB Swiss Institute of Bioinformatics Switzerland
- University of Lausanne Switzerland
- University of Basel Switzerland
- Autonomous University of Barcelona Spain
Sirolimus, Male, Aging, Proteome, QH301-705.5, Muscle Proteins, Mechanistic Target of Rapamycin Complex 1, Phosphoproteins, Article, Mice, Inbred C57BL, Mice, Animals, Biology (General), Phosphorylation, Muscle, Skeletal, Caloric Restriction, Signal Transduction
Sirolimus, Male, Aging, Proteome, QH301-705.5, Muscle Proteins, Mechanistic Target of Rapamycin Complex 1, Phosphoproteins, Article, Mice, Inbred C57BL, Mice, Animals, Biology (General), Phosphorylation, Muscle, Skeletal, Caloric Restriction, Signal Transduction
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).2 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!