Pharmacovigilance plays a key role in the health system through the evaluation, monitoring, and detection of drug interactions and their impact on humans. Therefore, drug safety requires monitoring of adverse reactions for each drug throughout its life cycle, during drug development, e.g. Pharmacovigilance deals with the detection, evaluation, understanding, and prevention of adverse effects. Metoprolol Observational studies suggest that beta-blockers may lower the risk of exacerbations and death in patients with moderate or severe chronic obstructive pulmonary disease (COPD), but randomized trials have not yet verified these findings. We can see Metoprolol's MOA and ADR in all of their forms. Metoprolol succinate, a BCS class I medication with a short half-life of 3–7 hours, is used to treat angina pectoris, heart attacks, and hypertension. The normal dosage is 25/50 mg three times each day. Due to the high frequency of delivery and oscillating plasma drug concentration, a sustained-release form of administration with prolonged clinical efficacy must be developed. To deliver the loading dose of the medicine in the stomach, decrease the frequency of administration, and boost the efficacy and bioavailability of the drug by delivering prolonged action, it is highly necessary to design a sustained-release bilayer.