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An Overview of Commonly Used Rodent Models for Studying PD-Related Cognitive Impairments

Authors: Polinski, Nicole;

An Overview of Commonly Used Rodent Models for Studying PD-Related Cognitive Impairments

Abstract

Cognitive dysfunction is a common issue in Parkinson’s disease (PD). Symptoms include impairments in working memory, learning, attention, cognitive flexibility, and social cognition. Cognitive dysfunction is found in 15-40% of patients, generally presenting as mild cognitive impairment at time of diagnosis and progressing to PD dementia in the decades following. The cognitive issues have been linked to dopaminergic, cholinergic, and noradrenergic circuits. In this report from the Preclinical Tools and Models Team at The Michael J. Fox Foundation for Parkinson's Research (MJFF), you will find a summary of rodent models that display cognitive dysfunction. Please note, this list is not comprehensive.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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Average
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