Objective: This narrative review seeks to compare the advances and efficacy of various anti-VEGF therapies in the treatment of diabetic retinopathy, using the PICO format. Methods: A comprehensive search of medical and scientific literature was conducted to identify studies investigating the efficacy of anti-VEGF therapies in the treatment of diabetic retinopathy. The PICO format guided the research question and review process. Accurate diagnosis, side effects, quality of life, and patient satisfaction were analyzed and compared for each treatment option. Results: Anti-VEGF therapies were shown to be effective in reducing the progression of diabetic retinopathy, improving visual acuity and decreasing macular edema. Although generally safe, differences in side effect profiles were observed between the different anti-VEGF agents. Conclusion: The selection of an appropriate Anti-VEGF therapy for diabetic retinopathy should consider accurate diagnosis, side effects, quality of life, and patient satisfaction. Although anti-VEGF therapies are promising, more research is needed to optimize their use and fully understand their benefits and limitations.