This dataset was generated to aid the creation of a review article addressing the use of Metal-Organic Frameworks (MOF)-based Surface Enhanced Raman Spectroscopy (SERS) platforms for the detection of Volatile Organic Compounds (VOCs). This dataset was generated employing the Web of Science database, encompassing manuscripts published up to March 2023. A literature search was initially conducted using a combination of keywords, including "MOF," "Metal-Organic Framework," "SERS," "Surface Enhanced Raman Spectroscopy," and "Surface Enhanced Raman Scattering." This search spanned the "Topic" category, enabling exploration across title, abstract, author keywords, and keyword-plus fields. From the initial pool of 238 documents, review articles and duplicates were systematically excluded, resulting in a refined collection of 182 articles. Subsequently, articles not concurrently addressing MOF and SERS or those utilizing MOF as sacrificial templates were further excluded, resulting in a final subset of 72 articles. From this curated set, relevant parameters were extracted, resulting in 229 entries for the dataset. Characteristics about the structure (in terms of MOF type and configuration; Plasmonic element type and configuration), target analyte (including type, phase, and incubation time), measurement specifications (in terms of laser, laser power, exposure time), and performance of the MOF-based SERS substrates were collected. Listed references 1-72 correspond with the manuscript number in the dataset. Listed references 73-80 correspond with references for selected examples of MOF pore diameters.