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ZENODO
Dataset . 2024
License: CC BY
Data sources: ZENODO
ZENODO
Dataset . 2024
License: CC BY
Data sources: Datacite
ZENODO
Dataset . 2024
License: CC BY
Data sources: Datacite
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UK Biobank MGUS GWAS Results

Authors: Güler, Murat; Canzian, Federico;

UK Biobank MGUS GWAS Results

Abstract

The UK Biobank is a large-scale biomedical database and research resource, containing genetic and health information from half a million individuals aged 40 to 69 years in the United Kingdom. The genotyping methods and quality control steps previously reported (PMID: 30305743). The MGUS cases were defined by using cancer registry data (Data-Field 40011 and Data-Field 40006) by using ICD-10 code D47.2 and ICD-O-3 code 9765. The control group was created by removing participants who had any cancer-related record in either another cancer registry, hospital record, or self-reported history of cancer. From the whole cohort, participants were removed if they reported non-white British ethnic background, sex chromosome aneuploidy, genetic relatedness exclusions, recommended genomic analysis exclusions, genetic and reported sex mismatch. After exclusion steps, a total of 107 MGUS cases and 277496 controls were used for GWAS analysis. The association models in both steps also included the following covariates: age (cases: age at diagnosis, controls: age at recruitment), sex, genotyping array, and the first 10 genetic principal components (PCs). Column Names in the summary statistics: CHROM: Chromosome GENPOS: HRCH_37 position ID:rsid ALLELE0: Non-effect Allel ALLELE1: Effect Allel A1FREQ: Freq of effect allel A1FREQ_CASES A1FREQ_CONTROLS INFO N N_CASES N_CONTROLS TEST BETA SE CHISQ LOG10P EXTRA SNP: SNP names in Chr:Pos:A0:A1 P

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Related to Research communities
Cancer Research