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Article . 2023
License: CC BY
Data sources: ZENODO
ZENODO
Article . 2023
License: CC BY
Data sources: Datacite
ZENODO
Article . 2023
License: CC BY
Data sources: Datacite
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Extrakt z levandule stimuluje hipokampálnu neurogenézu počas depresii podobných stavov laboratórnych zvierat / Lavender extract stimulates hippocampal neurogenesis during depression-like state of laboratory animals

Authors: Urbanská, Nikol; Kukeľová, Diana; Kisková, Terézia;

Extrakt z levandule stimuluje hipokampálnu neurogenézu počas depresii podobných stavov laboratórnych zvierat / Lavender extract stimulates hippocampal neurogenesis during depression-like state of laboratory animals

Abstract

SÚHRN Depresia je bežná neurologická porucha, ktorá postihuje takmer každého štvrtého človeka počas života. Liečba depresie je finančne náročná a sprevádzajú ju mnohé vedľajšie účinky antidepresív. Levanduľa sa v tradičnej medicíne používa pre svoje predpokladané antidepresívne vlastnosti ako aromaterapeutický prostriedok. Niektoré indície poukazujú na to, že levanduľa by mohla pôsobiť i na úrovni hipokampu. Preto cieľom tejto štúdie bolo určiť účinky levanduľového extraktu na proliferačnú aktivitu hipokampálnych prekurzorov počas stresom vyvolanej depresie potkanov kmeňa Wistar. Levanduľa spôsobila významné zvýšenie počtu mitoticky aktívnych buniek v hile hipokampu u samcov a samíc a v subgranulárnej zóne u samíc v porovnaní s depresívnymi zvieratami, pričom počet buniek dosiahol úroveň proliferácie prekurzorov zdravých jedincov. Levanduľa teda môže byť schopná zvýšiť proliferačnú aktivitu hipokampálnych prekurzorov počas depresie. ABSTRACT Depression is a common neurological disorder affecting almost every fourth person during the life. Natural substances do not have side effects at a certain dose, and could potentially supplement the standard treatment. Lavender is used in traditional medicine because of its presumed antidepressant properties as an aromatherapeutic agent. There are some indices assuming that lavender may act at hippocampal level. Thus, this study aims to determine the effects of lavender extract on the proliferative activity of hippocampal precursors during stress-induced depression in Wistar rats. Lavender caused a significant increase in the number of mitotically active cells in hilus of hippocampus in males and females and subgranular zone in females when compared to depressive animals, with cell numbers reaching the precursor proliferation level of healthy subjects. Thus, lavender may be able to increase proliferative activity of hippocampal precursors during depression.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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