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Figure S2: Probability of significant relationship between pazopanib's exposure/Ctrough and treatment outcomes/toxicity in mRCC and STS patients

Authors: Juřica, Jan;

Figure S2: Probability of significant relationship between pazopanib's exposure/Ctrough and treatment outcomes/toxicity in mRCC and STS patients

Abstract

The population proportion (mean and a 95% credible interval) of patients from studies in which a significant relationship between pazopanib exposure and treatment outcomes/toxicity was proven. The data were modelled as from binomial distribution under a Bayesian paradigm using an R package brms (Bürkner P (2017). “brms: An R Package for Bayesian Multilevel Models Using Stan.” Journal of Statistical Software, 80(1), 1–28. doi:10.18637/jss.v080.i01.) and weakly informative priors. Original dataset: Sum of the patients from the studies (STS=6, RCC=7) regarding the relationship between pazopanib Ctrough/exposure and treatment outcomes/toxicity: Indication Relationship-Yes (N) Relationship-No (N) Parameter N (patients) STS 107 38 Toxicity 145 mRCC 569 63 Toxicity 632 STS 103 69 Response 172 mRCC 540 56 Response 596

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