Introduction Subdural empyema is a collection of pus in the space between the dura and arachnoid, it is a rare type of intracranial infection. We report a case aged 1 month, with subdural empyema, the presentation was focal neurologic deficit, fever, vomiting, and seizures. Diagnosis was achieved by neurologic examinations and computerized tomography. Treatment was done by burr hole and antibiotics were administered. The patient made a good recovery without sequelae. We therefore recommend burr hole with catheter drainage plus antibiotics as a method of treating subdural empyema. We review previously published cases and highlight the uniqueness of the disease. The aim of this report is to discuss the clinical, radiological, and histological characteristics for optimal treatment of this rare case. Keywords: Subdural, empyema, burr hole, newly born.