Abstract : Novel drug delivery system is a new approach to deliver the active molecules in a safe and effective manner to produce desired pharmacological actions. Nano technology has played a major role in overcoming some drawbacks of conventional drug delivery system. Nanosponges are tiny bodies filled with drug, they circulate throughout the body until they encounter specific target site and releases drug in a controlled and predictable manner. The major goal of the study was to create doxazosin mesylate nanosponges and to evaluate them. Nanosponges are prepared by emulsion solvent diffusion approach, using Ethyl cellulose, β-CD and HP-β-CD.The FTIR test is used as a preliminary test, and it shows that the active ingredient and polymers have no interaction. The particle size, PDI, zeta potential, SEM, entrapment efficiency of nanosponges were assessed. The particle size ranged from 443.46 to 683.93 nm, PDI ranged from 0.255 to 0.510, zeta potential from – 19.8 to -22.9 mV and entrapment efficiency was ranged from 51.62 to 92.82%. The cumulative percentage release from all nanosponges varied from 52.76 to 91.84 % after 12 hours depending upon the drug and polymers ratio and F5 formulation showed highest drug release i.e., 91.84%.