The publication presents the results of the participatory process carried out by the FoodSafety4EU project, a Coordination and Support Action funded by the EU’s Research and Innovation Horizon 2020 programme. A multi-stakeholder group of selected experts has co- designed the contents, discussed and defined the main topics to be addressed by a new Strategic Research and Innovation Agenda (SRIA), that matches the future challenges of the European Food Safety System. The iterative process has been conducted by a project team led by IBA Bucharest, a partner of the FS4EU project, involving more than 30 experts in the discussion and confrontation, supported by professionals in social innovation, who have facilitated the implementation of the methodology. The final SRIA is presented to EU Commission, EFSA, JRC representatives, Universities, Research Centers, Industries, Producers and Consumers associations at the first European Food Safety Forum on 28 and 29 November 2023 in Brussels. This document is a summary of the SRIA, reporting and presenting:- SRIA description, the main challenges identified by the experts and the co-creation methodology- per each identified challenge:- selected topics - expected action plan/measures to be taken in medium or short term perspective for ensuring the transition towards a more comprehensive Food Safety System in Europe- expected outcomes - matrix on topics emergency vs uncertainty, representing the prioritization of the defined topics - areas of intervention, as main impact areas addressed by the SRIA.