Dental caries is a non-reversible infectious condition caused by microorganisms. Streptococci mutans, S.sobrinus, and Lactobacillus are the main causative agents of dental caries. S.mutans adheres to the tooth pellicle via adhesions. This leads to the synthesis of GTF and subsequent glucan production, facilitating the colonization of new organisms. Consequently, the initiation of lactic acid formation occurs, resulting in the development of dental caries. To intervene in the immune response, one can inhibit the receptors that are essential for the bacteria's colonization or deactivate GTF. By implementing these strategies, it is possible to achieve immunization against dental caries.