ABSTRACT:Background-Patellofemoral pain syndrome is one of the most common musculoskeletal overuse injuries of limb. The syndrome can affect 25% of population. Women are affected twice more often than men. Biomechanical factors include weaken medial bend with medial turning of femur, exaggerated Q-angle, pes planus and pes cavus with exaggerated inner arch. Muscle factors include quadriceps weakness, tightness of iliotibial band, hamstrings, adductors, external oblique and calf muscles. Treatment is given in form of open Kinetic chain exercises and closed Kinetic chain exercises versus closed Kinetic chain exercises with hip strengthening. This study was designed to compare the efficacy of these exercises on this syndrome.Materials & Methods- Total 30 patients suffering from the syndrome aged 35 to 60 years were allocated in two groups A and B using purposive random sampling. Group A received open Kinetic chain exercises and closed Kinetic chain exercises. Group B received closed Kinetic chain exercises with hip strengthening. Both groups participated for 4 weeks. Before and after the period outcome measures were assessed using VAS, NPRS and KUJALA questionnaire respectively. Data was analyzed using paired t-test, unpaired t-test, mean difference and standard deviation.Results - The study indicated that close Kinetic chain exercises along with hip strengthening exercises (Group B) for 4 weeks brought significant changes in relieving pain along with improving functional activities. Likewise, it was revealed that there was a significant pain relief as well as function improvement in Group A. Comparing two groups illustrated that benefits of closed Kinetic chain with hip strengthening outweighed open Kinetic chain and closed Kinetic chain exercises.Conclusion- Overall, both treatments were efficient in relieving pain as well as improving function. However close Kinetic chain with hip strengthening exercises were more effective.