The study aims to identify the most commonly prescribed drugs and drug categories in the ICU setting. The study was conducted retrospectively and observationally over a period of six months, involving the analysis of 100 patient case files. Data regarding the prescribed drugs were collected from the medical records department of the hospital and analyzed. The results revealed that the most frequently prescribed drugs in the ICU were Pantoprazole, Atorvastatin, Aspirin, Ondansetron, Acetaminophen, Ceftriaxone, and Levetiracetam. These medications were primarily used for gastric protection, cardiovascular treatment, and managing nausea and vomiting. In terms of drug categories, antibiotics were the most commonly prescribed category, followed by gastrointestinal (GI) drugs, antihypertensives, analgesics/antipyretics, bronchodilators, and anti-diabetic medications. These findings align with similar studies conducted in different settings. Overall, the study provides insights into the prescription patterns of drugs in the ICU, which can contribute to optimizing pharmacological management in the ICU and improving patient outcomes.