Diabetes mellitus (DM) is a worldwide health concern that necessitates efficient management to mitigate complications. Despite the critical role of medication adherence, non-compliance persists, especially among Type 2 DM patients. This prospective interventional study in Dakshina Kannada, India, aimed to assess and improve medication adherence in 100 Type 2 DM patients through pharmacist interventions over six months (January to June 2022). Collected data included demographics, social and medical history. The Morisky Medication Adherence Scale (MMAS-8) assessed adherence, with pharmacist interventions comprising education, counseling, and patient information leaflets. Pre-intervention, 56% exhibited low adherence, correlated with age, gender, education, employment, and treatment duration. Post-intervention, high adherence rose from 16% to 35%, medium adherence from 28% to 54%, and low adherence decreased to 11%. Influential factors included age, gender, education, employment, and treatment duration. Pharmacist interventions significantly improved adherence, underscoring the pivotal role of education and counseling. This study provides insights for managing chronic conditions and underscores the importance of tailored interventions for diverse patient profiles.