Calcinosis related to systemic sclerosis is a debilitating vascular complication that negatively affects quality of life. It results from the deposition of calcium hydroxyapatite in soft tissues that occurs in the presence of normal calcium and phosphorus metabolism. Injuries can be painful and cause tissue inflammation, ulcers with infections, or deformities that cause functional disability. We present the case of a 29-year-old woman with a history of calcinosis cutis associated with systemic sclerosis, lesions complicated by soft tissue infections, leading to septic arthritis. During the approach, improvement was achieved with the use of intravenous antibiotics and a long oral regimen. As it is a disease without definitive treatment, we improve the patient's living conditions and prevent future infections with non-pharmacological therapeutic measures.