Accordingly, the use of medical ozone in the treatment of placental insufficiency, which has a multifactorial nonspecific effect, seems promising. Medical ozone is an ozone-oxygen mixture obtained from ultrapure oxygen by decomposing it under a weak electric charge or under the influence of ultraviolet radiation. The aim of the study to improve the ways of carrying pregnant women with fetoplacental insufficiency using ozone therapy. The results of pregnancy and childbirth were studied in 38 patients diagnosed with fetoplacental insufficiency, who applied to the obstetrics department of the SamSMU multidisciplinary clinic No. 1 between 2022 and 2023. Thus, timely complex therapy of FPI using traditional and ozone therapy methods helped to correct changes in the blood coagulation system and normalize the hemostasiological parameters of the examined patients, in our study, blood coagulation due to plasma and platelet connections in the main group significant stabilization of potential was observed.