The drug delivery system has been advanced to release the drug according to the body requirement during the entire period of treatment and also for the delivery at the targeted site. Now days, several targeted treatment systems including magnetic field, electric field, ultrasound, temperature, UV light and mechanical force are being used in many disease treatments (e.g. cancer, nerve damage, heart and arrayment-diabetic, eye and other medical treatments). Magnetic microsphere is an alternative to traditional radiation methods. As the traditional radiation methods use highly penetrating radiation that is absorbed throughout the body and cause side effects hence its use is limited. Magnetic microspheres are one of the new novel drug delivery system in pharmaceutical field due to their biocompatibility, easy of surface modification and magnetic properties. They hold great result for reaching the goal of controlled and site-specific drug delivery. Therefore, a safe and effective alternate is needed like magnetic microsphere. The main aim of present study was to formulate and evaluate the Curcumin magnetic microspheres using natural polymers like Albumin and Chitosan in different ratios. The formulations were prepared by using Emulsion solvent diffusion evaporation technique. The prepared Curcumin magnetic microspheres were evaluated for Percentage yield, Drug loading and Entrapment efficiency, In-vitro Swelling index and In-vitro Dissolution studies. FT-IR studies showed significant compatibility between the drug and the polymer. Evaluation studies of swelling indicate an increase in swelling index with increase in concentration of polymers due to more uptake of solvent. The in vitro studies indicated that the rate of Curcumin release from magnetic microsphere decreased with increase in the amount of polymer. The study results proved that curcumin magnetic microspheres can be used for controlled drug delivery due to sustained drug release characteristic of polymers that used. The optimized formulation AMMS2 showed diffusion controlled sustained drug release mechanism and therefore can have benefits such as reduction in total dose and frequency of administration. Keywords: Magnetic microspheres, target drug delivery, Curcumin, Albumin, Chitosan