Datura stramonium is a widespread growing plant commonly known as Angel’s trumpet and it belongs to the family Solanaceae. The plant comprises bioactive constituents like scopolamine, hyosciamine, tropane alkaloids, tannin, proteins and carbohydrates. It has hallucinogenic effects as well as medicinal properties. Traditionally it is used in cough, fever, asthama and also in skin disorder. The plant has extensive pharmacological effect mainly analgesic in action. A substantial evaluation is contributory in scientific assessment of the medicinal properties of the plant. The ethnomedicinal, phytochemical as well as toxicological works upon Datura stramonium gives a better understanding of the particular plant. The present paper highlights upon the various properties of Datura stramonium respectively.