A few methods are reported for prerequisite of telmisartan in biological samples and spectrophotometric estimation in bulk and pharmaceutical formulation. Also methods have been reported for qualification of atorvastatin by HPLC, RP HPLC, voltametry and derivative spectrophotometry. But no methods reported for the simultaneous determination of Perindopril and Indapamide in bulk and dosage form. The objective of this work was to develop and validate simple rapid and accurate chromatographic methods determination of Perindopril and Indapamide in tablet dosage form. The method was based on reversed phase high performance liquid chromatography, on inertsil ODS column 250x4.6mm using Phosphate buffer: ACN: methanol (40:25:35:, v/v/v) pH 4.5 as mobile phase at a flow rate of 1ml/min at ambient temperature. The mean retention time of Perindopril and Indapamide was found to be 2.350 and 3.490 min respectively. The method was validated in terms of its linearity, accuracy, precision, robustness, ruggedness, LOD and LOQ. This method can be used for routine quality control analysis due to its simplicity and accuracy.