Cataract surgery is one of the most commonly performed surgical procedures in our ageing world. Cataract surgery is a major surgery as it is an intra-ocular surgery, technically challenging, with abundant scope for devastating complications like loss of sight. Advances in techniques including phacoemulsification and intraocular foldable silicone lens implantation through suture-less mini incisions decrease the surgical recovery period with lower complication rates and improved surgical outcomes. In this present study, an attempt was made to study the safety and efficacy of intra cameral infusion of Adrenaline during phacoemulsification. An observational prospective study was conducted in 150 patients in the ophthalmology department of a tertiary care hospital, Salem. The blood pressure, pulse rate and pupil size parameters were chosen to study the efficacy of adrenaline and the result did not show much fluctuation pre and intraoperatively. Pupillary constriction during phacoemulsification is found to be the major cause of iris damage, incomplete cortex removal, posterior capsular rupture, vitreous loss and even posterior lens material dislocation. So it is necessary to maintain mydriasis. Irrigation fluid containing Adrenaline is thought to be beneficial in this respect. Hence Adrenaline is safe and effective during the cataract surgery.