This deliverable provides all the support material that the project makes available for the applicants and participants of the Open Call of TrialsNet. The WP7, titled "Open Call and Support to Third Parties", is responsible for the management of the calls and to provide support to third parties in line with the project objectives and structure. In the context of WP7, the Task 7.1 (T7.1) "Open Call scope, documentation and evaluation process definition", is responsible for the preparation of material for the applicants in terms of a "Handbook for Applicants" which is this document. This "Handbook for Applicants" contains the text of the Open Call including the complete legal and administrative part, such as the methods with which the selection will be conducted, the opening conditions and transparency, the decision-making procedures for selecting proposals, eligibility, and exclusion conditions. In addition, support material for the applicant is also provided, including the technical description of the infrastructures and the use cases that will be implemented by the project, as well as a description of the KPIs and KVIs framework that will be validated through trials' activities.