Deliverable D5.5 addresses the reference guidelines for establishing an ethically sound and legally compliant network of computational nodes within HRIC. Those guidelines build in previous deliverables from the same work package and underscore the importance of aligning with maturity levels for processing health-related data of varying granularities. Striking a balance between intricacy and compliance, computational nodes are envisioned to form a distributed infrastructure, adapting to the availability of data and the potential for orchestrating distributed analyses. As the HRIC evolves beyond a technical blueprint, there's a recognised need to mature the ethical soundness of health-related data use. This ensures that HRIC transcends being a technical infrastructure, becoming a comprehensive framework for federated research infrastructures.