Abstract: The field of tissue engineering has witnessed significant advancements with the development of biodegradable scaffolds, offering promising solutions for regenerative medicine. This review article provides a comprehensive overview of biodegradable scaffolds, focusing on their application in tissue engineering. It begins with an introduction to tissue engineering and the pivotal role of scaffolds, emphasizing the importance of biodegradability. The methodology section outlines the processes involved in scaffold development, including material selection, fabrication techniques, and both in vitro and in vivo testing. The advantages and disadvantages of these scaffolds are critically analyzed, highlighting their biocompatibility and functionality versus challenges like mechanical stability and degradation rate variability. Ethical and regulatory considerations are discussed, underscoring the complexities of clinical applications and market introduction. The article concludes with a discussion on the current state, challenges, and future prospects of biodegradable scaffolds, emphasizing the need for continued research and interdisciplinary collaboration to overcome existing hurdles and fully realize their potential in clinical settings.