Sustainability of FAIR Life Science Resources and Projects: Lessons Learned from EOSC-Life Research Infrastructures This report summarises the key findings regarding sustainable LS resources, based on experiences from the EOSC-Life project. A more detailed description of EOSC-LIFE sustainably experiences and lessons learnt is contained in a companion publication (preprint link1) for which this report will provide an introduction. In the publication, we describe organisational, technical, financial and legal/ethical challenges using lessons from 27 scientific projects selected via open calls, and the work of RI teams. We describe the efficiency of the EOSC-Life support model for sustainable FAIR data management and explore the complex sustainability needs for sensitive- and industry-related data resources. A set of recommendations, which can be applied to other EOSC and data infrastructure projects, are given.