Objectives: To examine the heart failure patients self-care behavior and knowledge with heart failure. Methods: A descriptive cross sectional study was conduct, which was carried out at three major hospitals in Iraq started July 28th on 128 patients. Data were analyzed using IBM SPSS version 26. Both parametric and non-parametric statistical analysis approaches were used to analyze the collected data. The Dutch Heart Failure Scale and Self-Care of Heart Failure Index (SCHFI) were used to measure knowledge and self-care behaviors, respectively. Back to back translation approach was used to authenticate the translation in to Arabic language. The mean scores on the subscales of the Self-Care behavior of Heart Failure was poor self-care management 31.14 SD 3.47, self-care maintenance 31.14 SD 3.47, self-care confidence16.15 SD 2.35. The mean heart failure knowledge score was low at 4.28 SD 2.94. Results: The study indicated that patient had inadequate self-care levels and knowledge deficits Conclusion: The heart-failure patients showed low levels of self-care and knowledge. Keywords: Heart failure, Self-care, Chronic non-communicable disease, Patients.