This dataset comprises the perceived most challenging operations in the garment industry and the occupational discomfort faced by the workers. Collected through participant surveys, the dataset encompasses demographic information and work related parameters. The primary objective of this dataset is to identify and analyse the prevalence of MSDs in the most challenging operation in the garment industry. Researchers, ergonomists, and occupational health professionals can leverage this dataset to explore further for mitigating MSD risks in the industry. This dataset can be used for finding the Ergonomic interventions and workplace improvements. It can facilitate specific interventions for solving work related diseases among the garment workers. Anyone can use this dataset with proper citation. Note: This dataset adheres to ethical considerations, and participant information is anonymized to ensure confidentiality.