Modern advances in science make it possible to successfully deal with a number of diseases in an unborn child. A relatively new field of medicine, fetal medicine deals with precisely this problem and today is one of the fastest growing areas of medicine. One of the antenatal fetal pathologies requiring such high-tech minimally invasive methods of fetal treatment is non-immune hydrops fetalis. This article reviews the various aspects of non-immune hydrops fetalis, including the etiology, clinical presentation, antenatal diagnosis and treatment managements, as well as presenting some data on cases of non-immune hydrops fetalis treated in the newly established Fetal Medicine Department of the Republican specialized scientific-practical medical center of obstetrics and gynecology.