Deliverable 5.5 aims to collect the work conducted within task 5.3 "Safe by design strategies development", in particular subtask 5.3.1 (safe by material design strategies) and subtask 5.3.2 (safe by process design strategies). For subtask 5.3.1, we did an extensive literature review in order to come out with a library of well-balanced safe by material design strategies applied to different types of nanomaterials. Based on these general strategies, specific strategies that could be applied to the materials developed in DIAGONAL project have been proposed with the aim of being implemented later under the framework of task 5.4 "Safe by design strategies demonstration." Similarly, the work conducted under subtask 5.3.2 "Safe by process design strategies" focused on the exhaustive analysis of the production processes as well as the results obtained from the monitoring campaigns. According to this analysis, the proper safe by process design strategies have been proposed also considering, where applicable, the recommendation for implementing risk management measures (RMM) identified also in WP6. These strategies would be used as well as an input for the activities covered by Task 5.4, related to the demonstration of the SbD strategies within DIAGONAL case studies, as well as a base for the work that is being conducted in Task 5.5 "SbD best practices guidelines". It is worth to mention that the activities conducted in this task and the results reported in the current deliverable, are related to the work done before, specifically to the results reported in deliverable D5.1 "DIAGONAL SbD and SusbD implementation framework" in the third mont of the project which was aimed at implementing a theoretical framework for the subsequent development of Safe-by-Design (SbD) and Sustainability-by-Design (SusbD) strategies under the scope of High Aspect Ratio Nanoparticle (HARN) and Multi-Component Nanomateria (MCNM) production.