Abstract Objective: To determine whether MRI is more informative for the diagnosis of Autism compared with no brain imaging. Methodology: The PubMed electronic database was searched to extract relevant and appropriate studies. A lot of literature was explored, and six studies were included in this review. These studies were chosen after the proper exclusion, and inclusion criteria were applied. The included studies were then critically reviewed and analysed to extract the most important and valuable knowledge to produce desired results. Results: The studies that we have discussed so far have shown that there are a vast literature and evidence-based research available that supports our research topic that MRI is an informative and authentic diagnosis of Autism compared to no brain imaging. Majority of literature is available, which helps that MRI is a useful diagnostic method to rule out Autism. Conclusion: From the results of recent studies and literature, it is thus concluded that brain imaging such as MRI is increasingly used in the diagnosis of ASD (Autism spectrum disorders) and has also been confirmed by published studies.