Despite decades of research, metabolic risk factors have not been sufficiently studied. Few studies believe that gender can modify the effect of variants of metabolic changes in the disease. The study of sexual interactions can help to find out the underlying metabolic syndrome of changes and connections. We also examined the relationship of individual components of the metabolic syndrome with sex differences due to a lack of research in this area. In addition, we have also summarized the current understanding of the etiological mechanisms of how the metabolic syndrome or individual components lead to these differences. With the increasing amount of data on such associations, it may be important to identify patients who are at risk of developing metabolic syndrome, since rapid treatment and intervention can potentially reduce the risk of developing certain changes in the body.