Transdermal drug delivery is the non-invasive delivery of medications through the skin surface into the systemic circulation. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs. The advantage of transdermal drug delivery system is that it is painless technique of administration of drugs. Transdermal drug delivery system can improve the therapeutic efficacy and safety of the drugs because drug delivered through the skin at a predetermined and controlled rate. Due to the various biomedical benefits, it has attracted many researches. The barrier nature of stratumcorneum poses a danger to the drug delivery. By using microneedles, a pathway into the human body can be recognized which allow transportation of macromolecular drugs such as insulin or vaccine. These microneedles only penetrate outer layers of the skin, exterior sufficient not to reach the nerve receptors of the deeper skin. Thus the microneedles supplement is supposed painless and reduces the infection and injuries. Researches from the past few years showed that microneedles have emerged as a novel carrier and considered to be effective for safe and improved delivery of the different drugs. Microneedles development is created a new pathway in the drug delivery field. This review focus on new advances in transdermal drug delivery system using various carriers emphasizing mostly on the potential role of microneedles as transdermal system.