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ZENODO
Report . 2023
License: CC BY
Data sources: Datacite
ZENODO
Report . 2023
License: CC BY
Data sources: Datacite
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DEVELOPMENT OF MICROEMULSION BASED INTRANASAL DRUG DELIVERY SYSTEM FOR AN ANTI-PSYCHOTIC DRUG

Authors: *Damineni Saritha, Uroosa Arsheena, Anupama Koneru, P. Subhash Chandra Bose;

DEVELOPMENT OF MICROEMULSION BASED INTRANASAL DRUG DELIVERY SYSTEM FOR AN ANTI-PSYCHOTIC DRUG

Abstract

Purpose: The present study was intended to develop lurasidone micro emulsion for intranasal delivery in the treatment of psychosis. Methods: Sesame oil, tween-20(surfactant) and plurol oleique(co-surfactant) were selected based on the solubility of lurasidone. Pseudo ternary phase diagram was constructed to know the surfactant: co surfactant ratio which can form microemulsion. The prepared micro emulsion was characterized for FTIR, thermodynamic stability, droplet size and zeta potential, drug content, in-vitro diffusion study, stability study and release kinetics. Results & Conclusion: The ratio of surfactant to co surfactant 1:2 and 1:3 were selected from the pseudo ternary phase diagrams. Among all the formulations LA1 showed higher diffusion rate (99.11%) with a particle size of 3.957µm and zeta potential above 50mv. The optimised formulation was stable for a period of 3 months. Thus Lurasidone intranasal micro emulsion was developed which improved solubility and hence in-vitro diffusion of the drug. KEY WORDS: Micro emulsion, intranasal drug delivery, pseudo ternary phase diagram, zeta potential. 

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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