The purpose of this study to design a bi-layer floating tablets of hydroxy urea (HU) and ramosetron (RS) for delivering multiple pharmaceuticals with atypical release patterns, such as one layer of drug as immediate release (IR) for fast relief and a second layer of drug as sustained release (SR) for long-term effect and reduced dose frequency. The floating layer of HU provides a sustained release by using polymers such as guar gum, carbopal 34 and HPMC K100. The immediate release layer ramosetron developed by using sodium starch glycolate (SSG), crospvidone (CP) as super disintegrants. The tablets are prepared by direct compression method and evaluated for physic chemical parameters such as hardness, thickness, friability, weight variation, in vitro drug release and assay. The optimized formulation (H9) subjected to kinetic release models; the drug release fallows zero order. It can be concluded that the concept of bilayer floating tablets useful for extending the metabolism and improving the bioavailability. Key words: Bilayer floating tablet, Susatined release, Hydroxy Urea, and Ramosetron