The question of the sustainability of 1+MG infrastructure goes well beyond funding, comprising several dimensions such as scientific excellence, socio-economic impact or innovation. All these questions should be addressed over the entire life cycle - from initial planning up to decommission. In this deliverable, we compile different aspects that need to be taken into account for the future Genome Data Infrastructure (GDI) sustainability, resulting from the 1+MG initiative. Infrastructure needs Training needs Alignments with other initiatives and the EHDS Governance Investment needs Funding models Potential funding routes Socio-economic impact