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FORMULATION AND EVALUATION OF ITOPRIDE HYDROCHLORIDE CONTROLLED RELEASE TABLETS

Authors: Sirigadha Ramprasad;

FORMULATION AND EVALUATION OF ITOPRIDE HYDROCHLORIDE CONTROLLED RELEASE TABLETS

Abstract

In the present work, an attempt has been made to developed Controlled release tablets of Felodipine by selecting different types of Na CMC, HPMC K 100 and Sodium alginate as retarding polymers. All the formulations were prepared by direct compression method. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among the entire formulations 9 formulations showed maximum % drug release i.e., 98.68 % in 12 hours. Hence it is considered as optimized formulation F5 which contains HPMC K 100 (30mg). The optimized formulation dissolution data was subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Peppas release kinetics mechanism of drug release. Keywords: Felodipine, Na CMC, HPMC K 100, Sodium alginate and Controlled release tablets.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Green