Neurons are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from external world. Neurological disabilities include a wide range of disorder, such as epilepsy learning disabilities, neuromuscular disorders, autism, attention deficit disorder, brain tumours and cerebral palsy. Neuroprotection is the ability for a therapy to prevent neuronal cell death by intervening in and inhibiting the pathogenetic cascade that results in cell dysfunction and eventual death. Numerous natural products, but primarily plant extracts, have been reported to be used in traditional medicine for neuroprotective, memory enhancing, and antiaging purposes. Calotropis Procrera known as "milkweeds "which comes under the family of Apocyanacece. Ethanolic extract of Calotrpis procera that contains active chemical constituents such as flavonoids, tannins, phenols show neuroprotective activity. In view of this, the present study was aimed to evaluate neuroprotective activity of ethanolic extract of leaves of Calotropis Procrea in neuropathy induced rat model.