Introduction: Many studies have shown the role of various factors in the incidence of Pulmonary and extra-pulmonary tuberculosis. The patients have different clinical symptoms and depend on several factors, including host microbiological and the environment characteristics. Methods: In this review article, the databases Medline, Cochrane, Science Direct, and Google Scholar were thoroughly searched to identify the studies Extra-pulmonary tuberculosis. In this review, the papers published until early January 2017 that was conducted to study the Extra-pulmonary tuberculosis were selected. Findings: Tuberculosis is one of the oldest known diseases in humans; this disease is known to have high mortality rates, so that this rate might rise up to 50% in case of non-treatment. Mycobacterium has more than 100 species, some of which are pathogenic in humans and some others in animals. Conclusion: The probability of tuberculosis is one of the differential diagnoses that can be considered in the case of respiratory symptoms in these people. Consequently, designing an effective programs and screening patients opens new horizons for controlling and preventing tuberculosis. Keywords: Extra-pulmonary, tuberculosis