Teratogenicity is recognized as an important part of overall toxicology. The teratogenic risk factors are undetermined for more than 90% of drugs. The common teratogenic mechanism and effects are based on teratogenic compounds and severalagents known as physical agents,chemical agents, and biological agents. Millions of different chemicals are exposed by humans and they show negative impacts by penetratinginto human tissues, developing fetuses, and the reproductive health of humans. The teratogenic mechanism in pregnancy shows its effectson the developing fetus and sometimesit leads to suppression of fetal growth.It signifies the structural malformations during fetal development. It is a process by which congenital birth defects occur due some biological infections, pharmacological drugs, industrial pollutants, and maternal health problems.Teratology is the science that investigates the congenital malformations and their causes. Keywords: Teratogenicity, Human tissue, Management teratogens factors