Mitral valve regurgitation (MR) is a common valvular heart disease where an improper closure leads to leakage from the left ventricle into the left atrium. There is a need for less-invasive treatments such as percutaneous repairs for a large inoperable patient population. The aim of this study is to compare several indirect mitral annuloplasty (IMA) percutaneous repair techniques by finite element analyses. Two types of generic IMA devices were considered, based on coronary sinus vein shortening (IMA-CS) to reduce the annulus perimeter and based on shortening of the anterior-posterior diameter (IMA-AP). The disease, its treatments, and the heart function post-repair were modelled by modifying the living heart human model (Dassault Systèmes). A functional MR pathology that represents ischemic MR was generated and the IMA treatments were simulated in it, followed by heart function simulations with the devices and leakage quantification from blood flow simulations. All treatments were able to reduce leakage and the IMA-AP device achieved better sealing and there was a correlation between the IMA-CS device length and the reduction in leakage. The results of this study can help in bringing IMA-AP to market, expand the use of IMA devices, and help optimize future designs of such devices.

The data include: - The coordinates of the deformed valves in their systolic positions and information if the node is in contact or not. In addition, triangulation of the nodes based on their IDs is provided. All files are saved as CSV. - The coordinates of the SPH particles from the leakage models (CSV file) with STL files for the geometry of the cavities of the left verntricle and atrium.