Figure 1. Source data 1Figure 1. Source data 1 - Input and output text files containing all H1 and H3 virus data used in Figure 1, Figure1 Supplemental 1,2,3, filesFigure1.Source data 1.zipFigure 2. Source data 2Figure 2. Source data 2 - Input and output text files used to calculate H1 and H3 comparative rates of antigenic evolution and diversity shown in Figure 2 and Supplementary File 3_ Table 3Figure2.Source data 2.zipSupplemental Table 1. Source DataSupplemental Table 1. Source Data - Text files and plots of summary statistics of testing in 1, 2, 3, 4 and 5 dimensionsSupplemental Table1.Source Data.zipSupplemental Table 2. Source dataSupplemental Table 2.Source data Text infiles, phylogenetic trees and source script for antigenic distance analysesSupplemental Table 2.Source data.zipFigure 1Agif files for rotational views of 3D antigenic maps in Figure 1Figure1A.H1_lineages.gifFigure 1Bgif files for rotational views of 3D antigenic maps in Figure 1Figure1B.H1_regions.gifFigure 1Cgif files for rotational views of 3D antigenic maps in Figure 1Figure1C.H3_lineages.gifFigure 1Dgif files for rotational views of 3D antigenic maps in Figure 1Figure1D.H3_regions.gif

Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.