Background: Hallux Valgus is a type of plantar deformation that involves an angular deviation of the big toe, inwards, with respect to the long axis of the foot. This creates a state of chronic inflammation with a formation of protusion on articulation of big toe called bunion. As a consequence, people can lose capacity of deambulation and require the contribution of self-propelled supports. The treatment consists of surgery and use of non-steroidal anti-inflammatory drugs. A familiarity in this condition has also recently been highlighted. Objectives: To demonstrate, how the combined treatment with manual techniques and specific anti-inflammatory, cream is able to resolve plantar deformation without the aid of surgery and without recurrence. Methods: The synergistic combination of three manual techniques, as: Bowen Technique, Reflexology and Su Jok, coupled with a cream containing Glycerol, Camphor and Povidone Iodine, applied on a cohort of 30 patient, divided in 5 groups, was the basis of the clinical application. In order to confirm the efficacy of the preparation, its composition was compared, by Molecular Docking, with normal antinflammatory drugs. Results: The results from molecular docking showed a greater affinity, of the components of the cream, than the classical drugs. Furthermore, the statistic of the reduction of the size of bunions, showed a complete success in the reduction of volume of bunion, without recrudescence. Conclusions: The combined treatment of manual techniques, with the application of a cream, has shown full effectiveness in resolving the Hallux Valgus plantar deformation, without the appearance of recrudescence.