The aim of the present study was to examine the moderating role of self-esteem in the relationship between psychological well-being and loneliness among university international students. The sample (n = 129) was drawn conveniently from university international students. The age range of the sample was 18 to 40 years. The Psychological Well-being scale by Ryff CD [1] Rosenberg self-esteem [2] and UCLA loneliness scale was used to measure psychological well-being, self-esteem and loneliness respectively. Pearson correlation analysis was used to find the relationship among study variables. Hierarchical regression showed that self-esteem did not moderate the relationship between loneliness and psychological well-being. Independent sample t-test revealed that Female international students significantly have a higher level of loneliness than males.