This study is to find out and analyse the factors influencing job stress and job satisfaction and its impact on performance of Medical Representatives working under pharmaceutical industry,at Central Kerala districts (PALAKKAD, THRISSUR, ERNAKULAM and IDUKKI). We all know that increased stress leads to reduced productivity and also overall affects the overall performance.Stress is a universal phenomenon and common challenge to employee productivity,it is the unavoidable reality of modern day workplace.Apart from other professions, Medical Representative’s daily life or work involves continuous field work, continuous travelling, waiting for Dr visits, administrative work, sales pressure, and more.. Medical Representatives need to be always physically fit, mentally alert & attentive, presentable, punctual, patient, committed, responsive, skilled communicator, and an extrovert person to be able to succeed in the amazing competitive field of Pharmaceutical industry.