Android OS, which is the most prevalent operating system (OS), has enjoyed immense popularity for smart phones over the past few years. Seizing this opportunity, cybercrime will occur in the form of piracy and malware. Traditional detection does not suffice to combat newly created advanced malware. So, there is a need for smart malware detection systems to reduce malicious activities risk. Machine learning approaches have been showing promising results in classifying malware where most of the method are shallow learners like Random Forest (RF) in recent years. In this paper, we propose Deep-Droid as a deep learning framework, for detection Android malware. Hence, our Deep-Droid model is a deep learner that outperforms exiting cutting-edge machine learning approaches. All experiments performed on two datasets (Drebin-215 & Malgenome-215) to assess our Deep-Droid model. The results of experiments show the effectiveness and robustness of Deep-Droid. Our Deep-Droid model achieved accuracy over 98.5%.